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T14327 |
AS1949490
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|
Phosphatase
|
|
AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM. |
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T4534 |
BMS-309403
|
|
FABP
|
|
BMS-309403 is an effective, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM. |
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T22276 |
Bis(maltolato)oxovanadium(IV)
|
BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV) |
Phosphatase
,
Others
|
|
Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent i... |
|
T36665 |
Dehydro Nifedipine
|
BAY-b 4759 |
|
|
Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used i... |
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T67893 |
PTP1B-IN-22
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|
Phosphatase
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|
PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes. |
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T14017 |
2-NBDG
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|
Others
|
|
2-NBDG is a fluorescent indicator for direct glucose uptake measurement. It is an indicator of cell viability. |
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T33412 |
MitoPQ
|
MitoParaquat |
Glucokinase
,
transporter
|
|
MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhibits insulin-stimulated glucose uptake and translocation of... |
|
T20029 |
Buformin hydrochloride
|
NSC528218,NSC-528218,NSC 528218 |
AMPK
|
|
Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and... |
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T24793 |
SIRT6-IN-5
|
SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5 |
Sirtuin
|
|
SIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, ... |
|
T8526 |
Metformin
|
1,1-Dimethylbiguanide |
Mitophagy
,
AMPK
,
Autophagy
|
|
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm... |
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T69146 |
Suksdorfin
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|
PPAR
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|
Suksdorfin has hypoglycemic effects, promotes adipocyte differentiation and enhances lipocalin production, activates peroxisome proliferator-activated receptor gamma (PPARγ), promotes insulin-dependent glucose uptake by ... |
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T40413 |
SW157765
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|
transporter
|
|
SW157765 is a selective glucose transporter GLUT8 (SLC2A8) inhibitor, a prodrug of many compounds, that selectively inhibits the uptake of fluorescent 2-deoxyglucose (2DG) in SW157765-sensitive cells in a dose-dependent ... |
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T12853 |
SBI-477
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|
Others
|
|
SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal... |
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T8773 |
MID-1
|
|
Others
,
IGF-1R
|
|
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skelet... |
|
T22223 |
3PO
|
|
Glucokinase
,
Autophagy
|
|
3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decrea... |
|
TP2312 |
MOTS-c(Human) Acetate（1627580-64-6 free）
|
|
Others
,
AMPK
|
|
MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate ind... |
|
T25111 |
AS1938909
|
AS 1938909,AS-1938909 |
|
|
AS1938909 is a SHIP2 inhibitor that works by increasing Akt phosphorylation, glucose consumption, and glucose uptake in L6 myotubes, specifically upregulating the GLUT1 gene. |
|
T21399 |
Luseogliflozin
|
TS71,TS-071,TS 71,TS071,TS-71,TS 071 |
|
|
Luseogliflozin, a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2), competitively inhibits human SGLT2-mediated glucose uptake with a Ki value of 1.10 nM. |
|
T70862 |
AMPK Activator SC4
|
|
|
|
SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake. |
|
T26395 |
6-Benzylthioinosine
|
6-BT,6Benzylthioinosine,6-Bn-thioinosine |
|
|
6-Benzylthioinosine, a broad-spectrum metabolic inhibitor, inhibits glucose uptake, decreases glycolysis and ATP concentration with minimal changes in ROS and mitochondrial respiration. |
|
T23837 |
Buformin
|
W37,W 37,H 224,W-37 |
|
|
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class. It also inhibits the synthesis of glucose by the liver. Buformin delays absorption of glucose from the gastrointestinal tract increases ins... |
|
T30261 |
AZD6482 (S-isomer)
|
AZD-6482,AZD 6482,AZD6482 (S),AZD6482 |
|
|
AZD6482 (S-isomer) is a potent, selective, ATP-competitive PI3Kβ inhibitor (IC(50) 0.01 μm), which can inhibit insulin-induced in vitro glucose uptake by human adipocytes (IC(50) is 4.4 μm). |
|
T62409 |
PI3K-IN-23
|
|
|
|
PI3K-IN-23 is a (E)-9-oxooctadec-10-en-12-ynoic acid analogue that promotes glucose uptake (EC50: 7.00 μM). |
|
T81935 |
L-Glutamic γ-monohydroxamate
|
|
|
|
L-Glutamic γ-monohydroxamate is an antitumor compound that impedes cell proliferation and selectively hinders L-histidine uptake in microvascular endothelial cells. Additionally, this compound serves as a vanadium ligand... |
|
T61804 |
GSK-3β inhibitor 6
|
|
|
|
GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying vario... |
|
T64361 |
6-NBDG
|
|
Others
|
|
6-NBDG, a fluorescent glucose analogue, can be used as a fluorescent probe.6-NBDG can be used for monitoring glucose transport and uptake. 6-NBDG can be used as for detecting macrophage-rich atherosclerotic plaques. |
|
T83374 |
2-Quinizarincarboxylic acid
|
|
|
|
Compound 15, 2-Quinizarincarboxylic acid, functions as a glucose uptake inhibitor, demonstrating a 24.9% inhibition rate at a concentration of 50 μM [1]. |
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T71981 |
Gliclazide-d4
|
|
|
|
Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. ... |
|
T69380 |
Cinnamic acid, hydrazide
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|
|
|
Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various me... |
|
T79644 |
Antidiabetic agent 2
|
|
Glucosidase
|
|
Compound 56 (Antidiabetic agent 2) is a glucose-uptake promoter that inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase, with IC50 values of 0.036, 0.042, 0.241, and 0.185 μM, respectively. This agent effectively decre... |
|
TP1233 |
Amylin (8-37), rat
|
Amylin (8-37) (mouse, rat) |
|
|
Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin is also known as islet amyloid precursor peptide (IAPP) ... |
|
T78184 |
MMV009085
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|
|
|
MMV009085 is a potent inhibitor of the Plasmodium falciparum hexose transporter (Pf HT1), with potential as an anti-malarial agent. It also inhibits the human glucose transporter, demonstrating high potency with an IC50 ... |
|
T60858 |
MOPIPP
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|
|
|
MOPIPP is a novel indolebased chalcone that can cross the blood-brain barrier. MOPIPP inhibits the tumor progression agaisnt glioblastoma cells. MOPIPP induces cellular vacuolization as well as increases autophagosomes n... |
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T76039 |
MOTS-c(human) acetate
|
|
|
|
MOTS-c(human) acetate, a mitochondrial-derived peptide, induces the accumulation of AMP analog AICAR, enhances AMPK activation, and upregulates its downstream target, GLUT4. This compound promotes glucose uptake and enha... |
|
T37787 |
10-Nitrolinoleic acid
|
|
|
|
10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species. Other nitrolinoleates detected in human plasma and urine include 9-, 12-, and 13-nitrolinoleate. Nitrolinoleates activate peroxis... |
|
T78703 |
PTP1B/AKR1B1-IN-2
|
|
Phosphatase
|
|
PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0 and 0.9 μM. This compound acts as an insulin mimetic and enhan... |
|
T63866 |
GSK-3β inhibitor 7
|
|
|
|
GSK-3β inhibitor 7 is a GSK-3β inhibitor (IC50: 5.25 μM). GSK-3β inhibitor 7 acts by inserting into the ATP-binding binding pocket of GSK-3β and forming hydrogen bonds. GSK-3β inhibitor 7 has a high rate of glucose uptak... |
|
T37579 |
GW 1929 hydrochloride
|
|
|
|
Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and tr... |
